Human [Leu27]IGF-II

Human [Leu27] insulin-like Growth Factor-II ([Leu27] IGF-II) is an analogue of human IGF-II which has a Leucine substitution in place of Tyrosine at position 27 of the human IGF-II sequence. [Leu27]IGF-II has normal binding to acid-stripped human serum binding proteins but has a 10-20 fold reduction in binding to the type 1 IGF receptor compared to IGF-II. It is a useful analogue for studying the effects of IGF-II through non-type 1 receptor binding mechanisms.