Human Pro IGF-I E (71 – 86) antiserum (Rabbit)

Human ProIGF-I E (71-86) antiserum was prepared by immunising rabbits with a 16 amino acid peptide derived from the E domain of human ProIGF-I E linked to diphtheria toxoid. The peptide sequence is located immediately downstream of the cleavage site at the C terminus of mature IGF-I and as a consequence, the antiserum recognises all ProIGF-I E proteins derived from alternative splicing of the human igf-1 gene. It does not recognise mature IGF-I or IGF-II. It is likely to recognise ProIGF-I E proteins in non-human primates, rabbits and guinea-pigs but not other species due to alternative splicing of the igf-1 gene.