Human TGF-α (Receptor Grade)

Human Transforming Growth Factor-alpha (TGF-α) is a non-glycosylated, single chain, 50 amino acid polypeptide which is a member of the Epidermal Growth Factor (EGF) family of proteins. It promotes the proliferation and differentiation of many cell types displaying the EGF receptor. The biological effects of human TGF-α are likely to be mediated by autocrine and paracrine mechanisms in adult and embryonic cells as well as in a variety of tumours and transformed cells.