Human [Ala31] [Leu60] IGF-I

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Product description

Size
100 µg
Product code
ALU100

Human [Ala31][Leu60]insulin-like Growth Factor-I ([Ala31][Leu60]IGF-I) is an analogue of human IGF-I which has an Alanine substitution in place of Tyrosine at position 31 and a Leucine substitution in place of Tyrosine at position 60 of the human IGF-I sequence. [Ala31][Leu60]IGF-I has greatly reduced binding to the type 1 IGF receptor and to the insulin receptor compared to IGF-I, [Leu24]IGF-I and [Leu60]IGF-I. However [Ala31][Leu60]IGF-I has normal binding to acid-stripped human serum binding proteins. Consequently [Ala31][Leu60]IGF-I is an extremely useful analogue of IGF-I for investigating IGF actions largely independent of binding to the type 1 IGF receptor

 

Fact sheets

Human [Ala31] [Leu60] IGF-I specifications

Human [Ala31] [Leu60] IGF-I SDS

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