Human ProIGF-I EB (104-123) antiserum was prepared by immunising rabbits with a 21 amino acid peptide derived from human ProIGF-I EB linked to diphtheria toxoid. The peptide is located within the E domain of the 195 amino acid ProIGF-I EB, derived from alternative splicing of the human igf-1 gene. The antiserum recognises ProIGF-I EB but not ProIGF-I EA, ProIGF-I EC, mature IGF-I or IGF-II. Peptide sequence analysis suggest it may recognise ProIGF-I EB related proteins in a range of non-human primates but not many other species due to alternative splicing of the igf-1 gene. There is significant homology to similar regions of ProIGF-I variants in bovine, porcine and canine species to suggest it may be effective.
PRODUCT CODE: PAAT1
SIZE: 100 µl