Human IGFBP-rP1 is also known as IGFBP-7, MAC25 protein, PG12 stimulating factor, prostacyclin-stimulating factor and tumour derived adhesion factor. It is a 256 amino acid glycoprotein with significant structural homology to the true IGF binding proteins. It binds IGF-I and IGF-II with low affinity and also stimulates protacyclin production and causes cell adhesion.
The IGFBP-rP1 antibody was prepared by immunising rabbits with a 14 amino acid peptide from the Ig-like C2 type domain, linked to diphtheria toxoid. The antibody was affinity purified. The peptide sequence is unique to IGFBP-rP1. As a consequence, the antiserum recognises human IGFBP-rP1 but not other IGF binding protein or related proteins. Although the sequence is derived from human IGFBP-rP1, the antiserum should recognise IGFBP-rP1 in non-human primates, cattle, sheep and pigs and potentially a number of other species, although this should be experimentally determined.
PRODUCT CODE: PAAD1
SIZE: 20 µg